This two story frame mill was originally built on the Sac River at Turnback Creek in 1840 by Ezekiel Madison Campbell and powered with a large turbine that was turned by a waterwheel.   In  1848–1859 operations were ran by Campbell’s son-in-law, Henry H. Pemberton.  Pemberton sold to Henry Engleman, and he in turn sold to James C. Hulston in 1875.  In 1875 and after, a small economic community began to develop around the mill. This community became the Hulston Township.  Later, Hulston's son, John “Chris” Hulston, began operating the mill and in 1892, he added roller mills, powered by steam that could be used when water levels were low.  He completed this progressive task, shortly, before he was murdered.

Subsequent owners were P.G. Spencer, 1906–12; Nixon, 1912–1913; Samuel Farmer, 1914–1941; Baily Floyd, 1941–1941; Turrant Hickey, 1943–1946; J. Pemberton Nixon & A.F. Nixon, 1947–1964; and L.E. Meyer, 1965–1967.​  In 1967 to the present day, the Mill is owned by the Dade County Historical Society, a non-profit organization, dedicated to it's preservation and restoration.  In 1967 the Mill was moved about a mile and a half from it's original location on the Sac River to the Hulston Mill Historical Park location.  The move was necessary to save the Mill from flooding that would occur from the dam and formation of Stockton Lake.